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The synthesis and study of some of adamantane-fragment containing heterocycles.

Author: Marina Soselia
Co-authors: Shota Samsoniya, Davit Zurabishvili
Keywords: Adamantane, Benzimidazole, Amide, Biological activity
Annotation:

Aim of the research project is the development a synthetic method for adamantane-fragment containing some heterocyclic compounds. Studying of effect of electron donor radical of adamantine on reaction capacity and specific biological activity of compounds. Adamantane order derivatives were synthesized and accumulated: Adamantanecarboxylic acid, 3 -hydroxyadamantane-1-carboxylic acid, 3-chloroadamantane-1–carboxylic acid, acetylaminoadamantane-1 – carboxylic acid, acetaminophenyladamantane-1-carboxylic acid and their corresponding amino acids. Were obtained and purred benzoyl-o-phenylenediamine hydrochloride, 4-nitro-o-phenylenediamine, 4-methoxy-2-nitroaniline. 2-nitroacetaminoadamantane-1-carboxylic acid, N-benzoylaminoadamantane-1-carboxylic acid, N-adamantyl-3,4-diaminobenzophenon, N-(3-chloroadamantoil)-o-phenylenediamine, N-(3-chloroadamantoil)-2-nitroanizidine, N-(acetaminophenyladamantoil)-o-phenylendiamine and also benzimidazoles: 2-(2-hydroxyphenyl)benzimidazole and 2-(3-nitrophenyl)benzimidazole were synthesized. The structure of some synthesized compounds was determined by IR, 1H NMR, 13C NMR spectral data.


Lecture files:

ადამანტანის ფრაგმენტის შემცველი ზოგიერთი ჰეტეროციკლების შესწავლა: სინთეზი, კვლევა [ka]
The synthesis and study of some of adamantane-fragment containing heterocycles. [en]

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