Cholinergic counterpart in systemic Lithium action

Author: mikheil gedevanishvili
Keywords: Granulocytopoietic response, lithium carbonate, N-cholinergic blocking agent
Annotation:

Granulocytopoietic response to lithium carbonate (Li+) in rat was eliminated completely by N-cholinergic blocking agent, and independently by alpha-1-adrenergic antagonist. A link between these two contradictory events is explained by release of acetylcholine from the cholinergic preganglionic nerve endings in adrenal medulla triggered by Li+ ,and subsequent discharge of catecholamines (CA) from medullar chromaffin cells, which on their part activate adrenergic receptors of alpha-1 class on hematopoietic progenitor cells. Respectively, granulocytopoietic response to Li+ is blocked by cholinergic N-blocking agent at the level of adrenal medulla, and by the alpha-adrenergic blocking agent at the level of the hematopoietic cells proper. The stimulatory action of Li+ on granulocytopoietic cells is indirect, while is mediated by CA release from adrenal chromaffine cells. Experimental findings suggesting cholinergic nature of neuronal activity in CNS evoked by lithium are increasingly accumulating

Lecture files:

Gedevanishvili_Eng [en]
Gedevanishvili_Geo [ka]